2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-CE01796A
    trans-Geranyl-CoA 98%
    trans-Geranyl-CoA (trans-Geranyl-coenzyme A) is a coenzyme A derivative.
    trans-Geranyl-CoA
  • HY-CE01910A
    (S)-trans-2-Enoyl-OPC6-CoA
    (S)-trans-2-Enoyl-OPC6-CoA ((S)-trans-2-Enoyl-OPC6-coenzyme A) is a nucleoside metabolite.
    (S)-trans-2-Enoyl-OPC6-CoA
  • HY-CE02011A
    trans-3-Hexenoyl-CoA sodium
    trans-3-Hexenoyl-CoA (3-trans-Hexenoylcoenzyme A) sodium is a coenzyme A derivative.
    trans-3-Hexenoyl-CoA sodium
  • HY-CE02036S
    Tropoyl-CoA-13C2
    Tropoyl-CoA-13C2 (Coenzyme A, tropoyl-13C2) is a coenzyme A derivative.
    Tropoyl-CoA-13C2
  • HY-CE02037A
    2,2-Dimethyl-butyryl-CoA sodium
    2,2-Dimethyl-butyryl-CoA sodium is a coenzyme A derivative.
    2,2-Dimethyl-butyryl-CoA sodium
  • HY-N0215S13
    L-Phenylalanine-d1 54793-54-3 99.5%
    L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-d1
  • HY-N0215S16
    L-Phenylalanine-13C-1 136056-01-4 98%
    L-Phenylalanine-13C-1 ((S)-2-Amino-3-phenylpropionic acid-13C-1) is the 13C-labeled L-Phenylalanine (HY-N0215). L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (Kb of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-13C-1
  • HY-N0229S11
    L-Alanine-1-13C,15N 141794-74-3 98%
    L-Alanine-1-13C,15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1-13C,15N
  • HY-N0229S14
    L-Alanine-15N,d4 98%
    L-Alanine-15N,d4 is the deuterium and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-15N,d4
  • HY-N0378AGL
    D-Mannitol, M200 (GMP Like) 69-65-8
    D-Mannitol, M200 (GMP Like) (Mannitol, M200 (GMP Like)) is the GMP Like class D-Mannitol that can be used as pharmaceutical excipients. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells.
    D-Mannitol, M200 (GMP Like)
  • HY-N0378BGL
    D-Mannitol, M100 (GMP Like) 69-65-8 98%
    D-Mannitol, M100 (GMP Like) (Mannitol, M100 (GMP Like)) is the GMP Like class D-Mannitol that can be used as pharmaceutical excipients. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells.
    D-Mannitol, M100 (GMP Like)
  • HY-N0390S11
    L-Glutamine-2-13C 180991-02-0 98%
    L-Glutamine-2-13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine-2-13C
  • HY-N0486S11
    L-Leucine-d1 89836-93-1 98%
    L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-d1
  • HY-N0486S13
    L-Leucine-15N,d10 98%
    L-Leucine-15N,d10 is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-15N,d10
  • HY-N0830S11
    Palmitic acid-d2-1 62690-28-2 98%
    Palmitic acid-d2-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d2-1
  • HY-N0830S13
    Palmitic acid-d4-2 75736-57-1 98%
    Palmitic acid-d4-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d4-2
  • HY-N0830S17
    Palmitic acid-d2-4 30719-28-9 98%
    Palmitic acid-d2-4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d2-4
  • HY-N0830S19
    Palmitic acid-d2-5 1219805-64-7 98%
    Palmitic acid-d2-5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d2-5
  • HY-N0830S20
    Palmitic acid-d9 1173022-49-5 98%
    Palmitic acid-d9 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d9
  • HY-N0830S21
    Palmitic acid-d5 1219802-61-5 98%
    Palmitic acid-d5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d5
Cat. No. Product Name / Synonyms Application Reactivity